• Organism identified by biopsy, cytology, positive culture, molecular techniques, or

• Antibody titer (either IgM or IgG) ≥ 1:16 PLUS compatible clinical findings

• Antibody titer (either IgM or IgG) ≥1:4 and ˂1:16 PLUS compatible clinical findings

• Antibody titer (either IgM or IgG) positive but <1:4 PLUS compatible clinical findings

• Does not meet the case definition of CONFIRMED, PROBABLE or SUSPECTED, or

• No compatible clinical findings AND antibody titer <1:4 (i.e. incidental low positive titer)

Animal has at least one of the disease syndromes below. Respiratory disease is the most common finding in dogs, while lameness is the second most common. Skin lesions are the most common in cats.

Respiratory:
Cough AND at least one of the following: fever, anorexia, weight loss, radiological evidence of pulmonary disease or response to systemic antifungal treatment.

Bone disease:
Lameness with focal or multi-focal bone pain AND at least one of the following: fever, anorexia, weight loss, radiological evidence of bone disease or response to systemic antifungal treatment.

Cutaneous disease:
Draining, ulcerating or mass-like skin lesions that is either non-responsive to antibacterial therapy AND/OR responsive to antifungal therapy.

Disseminated disease:
3 of the following findings must be present: fever, anorexia, weight loss, enlarged lymph node(s), weakness, seizures, ataxia, keratitis, uveitis, acute blindness, vomiting, diarrhea, heart failure or response to systemic antifungal treatment.

1n general, cases are considered to be "Other" or "Unknown" unless the history indicates no travel outside of area.

• UNKNOWN- Less than 2 months of travel history available.

• LA COUNTY - No travel outside of LA County in the 2 months before first onset of disease

• SO CAL - No travel outside of southern California in the 2 months before first onset of disease

• OTHER - Dog traveled or lived outside of southern California into other areas that are endemic for Coccidioidomycosis in the two months before first onset of disease.

For the purpose of this case definition Southern California includes the following counties: Los Angeles, Orange, San Luis Obispo, Kern, Santa Barbara, Ventura, San Bernardino, Riverside, San Diego & Imperial.

• Greene, R. (2012) Coccidioidomycosis and Paracoccidioidomycosis. In C. E. Green (Ed) Infectious diseases of the dog and cat. 4th ed. (pp. 634-645). St. Louis, MO: Elsevier Saunders.

• California Department of Public Health Coccidioidomycosis Case Definition (See page 5 of form)

• Valley Fever Center for Excellence, University of Arizona.

• National Notifiable Diseases Surveillance System (NNDSS) Coccidioidomycosis (Valley Fever) (Coccidioides spp.) 2011 Case Definition