The differences between the impact of pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) on HIV disease progression is not well understood. Although EPTB is considered a more severe form of disease than PTB in clinical staging systems, there is limited population-based research on sufficient sample sizes with follow-up data that compares the disease course of PTB and EPTB in persons with AIDS. This project uses data from a CDC- funded project to compare the levels of immunosuppression, rates of opportunistic infections, and survival, for a population-based sample of persons with AIDS with PTB and EPTB using follow-up data over a three-year period
- To compare the demographic, clinical and mortality characteristics of persons with AIDS and EPTB to persons with AIDS and PTB.
- To compare the demographic, clinical and mortality characteristics of persons with AIDS with TB of any type to persons with AIDS without TB.
The study design is a population-based survey of AIDS cases reported in 1993 and coinfected with TB from 1991 to 1993. Medical record reviews were conducted every six months on 382 persons with AIDS and TB to collect data on CD4 counts, use of antiretroviral medications and PCP prophylaxis, the development of opportunistic infections and death. A control group of persons reported with AIDS in 1993 with no TB diagnosed from 1991 to 1996 was also constructed for purposes of comparison to the coinfected study group. Data were collected from hospitals and clinics throughout Los Angeles County.
Amy Wohl, Ph.D.